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KMID : 0370220120560040230
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Yakhak Hoeji
2012 Volume.56 No. 4 p.230 ~ p.235
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Synthesis of Novel Cyclopropyl Nucleoside Derivatives as Potential Antiherpetic Agent
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Kang Jin-Ah
Chun Pu-Soon
Moon Hyung-Ryong
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Abstract
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Synthesis of novel cyclopropyl pyrimidine and purine nucleoside derivatives 2~8 with α-configuration was successfully accomplished using an epoxide-ring opening reaction, lactonization, a hydroboration-oxidation reaction and a Mitsunobu reaction as the key steps. Antiviral activities against HSV-1 and -2, HIV-1 and -2, coxsackie B1and B3 viruses and poliovirus were assayed. Three compounds 4, 7 and 8 exhibit cytotoxicity-derived antiviral activity only in HIV-1 and -2.
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KEYWORD
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HSV, nucleosides, Mitsunobu reaction, virus, α-configuration
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